Detailed view for ML0020c

Basic information

TDR Targets ID: 257215
Mycobacterium leprae, Possible serine/threonine phosphatase PstP

Source Database / ID:  Leproma 

pI: 4.7506 | Length (AA): 509 | MW (Da): 53545 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13672   Protein phosphatase 2C

Gene Ontology

Mouse over links to read term descriptions.
GO:0004722   protein serine/threonine phosphatase activity  
GO:0003824   catalytic activity  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 237 1txo (A) 6 240 95.00 0.0000000011 1 1.63209 -1.4
33 144 3rnr (A) 12 119 30.00 0.19 0.95 0.456839 0.69
35 235 3qn1 (B) 243 501 27.00 0.042 1 0.444692 0.51
89 235 4n0g (A) 215 389 29.00 0.004 1 0.591602 -0.32
424 502 4hu2 (A) 59 135 16.00 0 0.05 0.427906 -1.7
424 500 2yn3 (D) 5079 5150 24.00 0 0.07 0.442977 -1.5
472 507 1nay (A) 107 140 32.00 0.33 0.01 0.315127 0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 1TXO:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2CM1:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136773)

Species Accession Gene Product
Chlamydia trachomatis CT_259   PP2C phosphatase family protein
Mycobacterium leprae ML0020c   Possible serine/threonine phosphatase PstP
Mycobacterium tuberculosis Rv0018c   Phosphoserine/threonine phosphatase PstP
Mycobacterium ulcerans MUL_0022   serine/threonine phosphatase PstP
Oryza sativa 4328913   Os02g0255100

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Calcineurin (3.1.3.16 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

  • Reagent:
  • Target Type Source Notes
    ML0020c cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 )

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier ML0020c (Mycobacterium leprae), Possible serine/threonine phosphatase PstP
Title for this comment
Comment